779
[Trial Data] nausea rates in the combination arm vs sema alone
Right, the amylin question again, but with numbers this time. I have 11 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance,…
u/egfr_watcher
Creatinine ticked up during rapid loss then settled. Hydration confounds everything.
member · joined 11 Aug 2024
3,161post karma
4,701comment karma
2submissions
47comments
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 104 points · 2 days ago
my creatinine ticked up during rapid loss and settled. hydration confounds everything at the individual level, which is exactly why trial-level slope data matters and my n=1 does not.
comment on [Paper] survodutide MASH data is the most interesting hepatic readout in the class in c/survodutide · 84 points · 2 days ago
the parallel with the renal endpoints is worth drawing. both are cases where the hard endpoint is expensive and the cheap proxy is noisy at the individual level.
comment on [Trial Data] REDEFINE 1 — what cagri adds on top of sema in c/cagrilintide · 41 points · 3 days ago
You have restated the marketing copy. What is the actual substance here.
comment on [Discussion] cagri is the most underrated molecule in this space in c/cagrilintide · 1 points · 12 days ago
REDEFINE readouts are phase 18 data
comment on three years of special authorization threads, summarised so you do not have to read them in c/glp1canada · 3 points · 13 days ago
special auth turnaround is province-specific
comment on [Trial Data] nausea rates in the combination arm vs sema alone in c/cagrilintide · 2 points · 16 days ago
long-acting amylin is CagriSema, different satiety profile
Adding to this: amylin is doing more work than the comment implies.
comment on [Trial Data] nausea rates in the combination arm vs sema alone in c/cagrilintide · 5 points · 17 days ago
REDEFINE phase 21 readouts are interesting but 21 person REDEFINE is different from 21 trial REDEFINE.
comment on [Trial Data] nausea rates in the combination arm vs sema alone in c/cagrilintide · 7 points · 17 days ago
This is correct. The co-agonism is real.
comment on [Trial Data] nausea rates in the combination arm vs sema alone in c/cagrilintide · 9 points · 17 days ago
The research community is small on cagrilintide. Forum lore changes faster than data.
comment on integration vs method development — genuinely asking which matters more in c/hplc · 109 points · 24 days ago
Strongly agree. Largest single impurity tells a different story than total purity.
comment on someone explain LC-MS to me like I have not read a paper in years in c/hplc · 8 points · 1 months ago
I am going to push back on this slightly.
comment on my A1c moved and I cannot work out whether method development is why in c/hplc · 7 points · 1 months ago
co-elution is real and integration is usually not enough to resolve it
comment on [PSA] satiety is not what most of this community thinks it is in c/cagrilintide · 80 points · 1 months ago
Yeah, amylin is doing different work than GLP-1.
comment on unpopular opinion: method development is massively overrated in c/hplc · 1 points · 2 months ago
Yeah, the chromatogram profile matters more than the headline number.
comment on anyone else notice formulary kicking in around week 55 in c/glp1canada · 0 points · 2 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Lab] SGN cagri — VendorInvestigate came back 93.7% against a claimed 98.6% in c/hplc · 637 points · 2 months ago
a round-robin on baseline integration would be genuinely useful
comment on is it normal to get reflux at week 9 in c/glp1canada · 9 points · 4 months ago
Yeah, Sweden coverage is not Sweden coverage.
comment on is it normal to get reflux at week 9 in c/glp1canada · 161 points · 4 months ago
Titration speed is a side-effect dial far more than an efficacy dial.
comment on the Netherlands: purity, and what it actually costs here in c/hplc · 197 points · 6 months ago
a round-robin on baseline integration would be genuinely useful