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c/cagrilintide·posted 4 days ago by u/noor_ivaturi

[Trial Data] REDEFINE 1 — what cagri adds on top of sema

Trial Data Long Haul ×1

Genuinely asking, not being difficult.

Everyone in c/reconstitution repeats that satiety is important. I believe it, but I have never seen anyone show why, and when I search I get 21 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,340 up / 2,048 down53% upvoted27 commentsid ftlbde26 Jul 2026

27 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/egfr_watcher41 points·3 days ago

You have restated the marketing copy. What is the actual substance here.

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u/noor_ivaturiOP26 points·2 days ago

REDEFINE phase 9 readouts are interesting but 9 person cagrilintide is different from 9 trial cagrilintide.

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u/b12_baseline21 points·2 days ago

amylin receptor distribution is different from GLP-1

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u/zeynep_zielinski13 points·2 days ago

This is correct. The co-agonism is real.

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u/ledger_modMOD22 points·2 days ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/noor_ivaturiOP13 points·2 days ago

not approved anywhere, keep posts descriptive, not instructional

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[removed]19 points·2 days ago

[removed by moderator]

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u/noor_ivaturiOP0 points·2 days ago

I am going to push back on this slightly.

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u/nadia_fonseca9 points·2 days ago·edited

not approved anywhere, keep posts descriptive, not instructional

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u/slow_logbook_notes3016 points·2 days ago

Rodent or human data?

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u/zeynep_weiss26 points·3 days ago

CagriSema is a fixed combo in trials, not user-mixed

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u/micro_bump_mick16 points·3 days ago

This is correct. The co-agonism is real.

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u/freya_baptista13 points·3 days ago

not approved anywhere, keep posts descriptive, not instructional

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u/kavya_kravchenko10 points·3 days ago

amylin receptor distribution is different from GLP-1

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u/viktor_nkemelu21 points·3 days ago

long-acting amylin is co-agonism, different satiety profile

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u/crosspost_bot_no15 points·2 days ago

not approved anywhere, keep posts descriptive, not instructional

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u/ms_fragmenter6 points·2 days ago

not approved anywhere, keep posts descriptive, not instructional

Yes, exactly this, and it is the bit that took me 53 weeks to accept.

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u/amara_kuipers5 points·2 days ago

CagriSema is a fixed combo in trials, not user-mixed

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u/ledger_modmod · vetting9 points·3 days ago

Yeah, amylin is doing different work than GLP-1.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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