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c/cagrilintide·posted 18 days ago by u/egfr_watcher

[Trial Data] nausea rates in the combination arm vs sema alone

Trial Data Slow Clap ×9

Right, the amylin question again, but with numbers this time.

I have 11 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 26, not week 75. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

846 up / 67 down93% upvoted27 commentsid ezmiah11 Jul 2026

27 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/hub_opssite staff47 points·16 days ago

REDEFINE which arm?

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u/plain_titration41 points·17 days ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/sanne_laurent10 points·17 days ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/laila_dumitru20 points·17 days ago

CagriSema is a fixed combo in trials, not user-mixed

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u/noor_hovland6 points·17 days ago

This is correct. The co-agonism is real.

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u/rekha_mwangi5 points·17 days ago

REDEFINE readouts are phase 6 data

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u/helga_vermeulen3 points·17 days ago

tendon and CagriSema literature in rodents is interesting

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u/amylin_amyamylin22 points·17 days ago

long-acting amylin is co-agonism, different satiety profile

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u/ledger_modMOD13 points·17 days ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/egfr_watcherOP5 points·17 days ago

REDEFINE phase 21 readouts are interesting but 21 person REDEFINE is different from 21 trial REDEFINE.

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[removed]4 points·17 days ago

[removed by moderator]

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u/ice_pack_auditcold chain6 points·16 days ago

the mechanism is different, the side effect profile reflects it

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u/egfr_watcher7 points·17 days ago

This is correct. The co-agonism is real.

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u/amara_halonen5 points·16 days ago

long-acting amylin is CagriSema, different satiety profile

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u/egfr_watcherOP2 points·16 days ago

long-acting amylin is CagriSema, different satiety profile

Adding to this: amylin is doing more work than the comment implies.

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u/yara_mensah17 points·17 days ago

This is correct. The co-agonism is real.

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u/forest_plot_fionastats12 points·18 days ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/egfr_watcherOP9 points·17 days ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/sten_rautio13 points·17 days ago

Respectfully this is a sample of one presented as a finding.

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u/ines_ekstrom0 points·17 days ago

long-acting amylin is CagriSema, different satiety profile

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u/zeynep_ndiaye6 points·17 days ago

Strongly agree. REDEFINE is phase 7, not final.

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u/noor_vermeulen-28 points·17 days ago

Yeah, amylin is doing different work than GLP-1.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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