u/elin_varga

I am going to push back on this slightly.

baseline is the most important baseline labs measurement, you cannot collect it later

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

Every time this gets posted it hits the front page and every time someone has to re-explain it.

the people who came off and restarted without shame

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

This is the "correlation is mechanism" thing again. You changed three variables at once.

Not to be pedantic but rodent data and tendon are being used interchangeably and they are not interchangeable in real life.

external review is the appeal after insurance says no

External review overturned the denial. Took 2 weeks but the process exists.

baseline is the most important ALT measurement, you cannot collect it later

Did you get step therapy or outright denial?

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

Switched from sema at 0.5mg to tirz at 5mg. Different drugs, cannot compare the doses directly.

SURMOUNT data is messier than STEP data but the weight loss is there

Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Strongly agree. ALT is where you catch the liver story early.