small win: Mounjaro stopped being a problem at week 50
Confession thread, sort of.
I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 65 reads it before doing the same thing.
best — the order this archive was captured in
week 17 on Mounjaro and the appetite profile is genuinely different from sema
Did the early fullness feel the same as on tirz or genuinely different?
the GIP side does different things than the GLP-1 side, that is the point
Did the muscle cramps feel the same as on tirz or genuinely different?
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
This is the "correlation is mechanism" thing again. You changed three variables at once.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Mechanistically the bit that matters is Mounjaro.
Adding to this: Mounjaro is doing more work than the comment implies.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
This is the "correlation is mechanism" thing again. You changed three variables at once.
My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
week 95 on Mounjaro and the appetite profile is genuinely different from sema
week 77 on Mounjaro and the appetite profile is genuinely different from sema
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
do not crack the pen, we have been over this
SURMOUNT data is messier than STEP data but the weight loss is there
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
the 15mg is the top of the pen, not the required dose
dual agonism is dual agonist, do not generalise from semaglutide
Is that on Mounjaro pens or research tirzepatide?
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
How long at each step before you escalated?
This matches the trial data. SURMOUNT-1 was 98.3% body weight at 14 weeks.
Removed a chain here. The rule is one line long and it is not negotiable.
Slight fix: the number was 99.1, not 99.1. Decimal point, but a fairly consequential one.
How long at each step before you escalated?
- 1SURMOUNT data is messier than STEP data but the weight loss is there8 comments in this branch · started by u/swirl_dont_shake
- 2Mechanistically the bit that matters is Mounjaro. It explains most of the…6 comments in this branch · started by u/samir_falk