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c/tirzepatide·submitted 1 year ago by u/emil_okwuosa

small win: Mounjaro stopped being a problem at week 50

Labbranch of 8 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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8 comments, started 1 year ago
u/swirl_dont_shakereconstitution81 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/sofia_nascimento32 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/sten_palacios18 points·1 year ago

the 15mg is the top of the pen, not the required dose

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u/graph_it_gary41 points·1 year ago

dual agonism is dual agonist, do not generalise from semaglutide

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u/ignacio_vanhecke44 points·1 year ago

Is that on Mounjaro pens or research tirzepatide?

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u/elin_varga26 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/georgi_chowdhury11 points·1 year ago

How long at each step before you escalated?

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u/throwaway_wl20263 points·1 year ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 14 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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