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c/tirzepatide·submitted 1 year ago by u/emil_okwuosa

small win: Mounjaro stopped being a problem at week 50

Labbranch of 6 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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6 comments, started 1 year ago
u/samir_falk167 points·1 year ago

Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.

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u/kian_ekstrom-29 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/hassan_nilsen115 points·1 year ago

Mechanistically the bit that matters is Mounjaro.

Adding to this: Mounjaro is doing more work than the comment implies.

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u/incretin_ivypharmacology96 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/zeynep_zielinski73 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/emil_okwuosaOP0 points·1 year ago

My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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