u/emil_okwuosa

This is the "correlation is mechanism" thing again. You changed three variables at once.

do not crack the pen, we have been over this

stalled on sema, tried tirz, and the curves were actually different shapes

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

glycaemic control first, that is the original indication

The dual agonism story is real. The appetite is physically different from semaglutide alone.

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

week 85 on Mounjaro and the appetite profile is genuinely different from sema

ALT is where the fatty-liver story shows up first

Crossposting this to c/reconstitution because the people who need it are not reading this community.

type 2 is the indication, weight loss is the side effect

the dual agonism hits different and that is why people describe it differently

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

API transparency is the question that separates good compounders from sketchy ones

the dual agonism hits different and that is why people describe it differently

ApoB from 3 to 32 is movement, not noise

This is correct. ApoB is the better marker.

SURMOUNT data is messier than STEP data but the weight loss is there

What are you comparing it against though?

My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.