u/ferran_mensah

do not crack the pen, we have been over this

Small correction: the trial was 22 weeks, not 25. Does not change your point but people will quote it.

the 503A/503B distinction is load-bearing, do not blur it

week 91 on Mounjaro and the appetite profile is genuinely different from sema

Sceptical. If this were true we would see it reflected in the data and we do not.

This is the "correlation is mechanism" thing again. You changed three variables at once.

Did they tell you their API source or dodge the question?

fertility signal is there but unclear

What are you comparing it against though?

PCOS and insulin resistance

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

telehealth prescriber models exist, pricing differs by state

fertility signal is there but unclear

SURMOUNT data is messier than STEP data but the weight loss is there

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

Zepbound and Mounjaro are literally the same drug, the name is the only difference

the GIP side does different things than the GLP-1 side, that is the point

SURMOUNT data is messier than STEP data but the weight loss is there

private prescription routes vary by region

Adding to this: pricing is doing more work than the comment implies.

tendon and CagriSema literature in rodents is interesting