small win: GIP stopped being a problem at week 41
Week 78 update. 19kg down from the start, early fullness basically gone since about week 23.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 5 weeks.
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the GIP side does different things than the GLP-1 side, that is the point
do not crack the pen, we have been over this
Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.
Small correction: the trial was 14 weeks, not 24. Does not change your point but people will quote it.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
The dual agonism story is real. The appetite is physically different from semaglutide alone.
do not crack the pen, we have been over this
the GIP side does different things than the GLP-1 side, that is the point
The dual agonism story is real.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
Week 6 on Mounjaro and 34kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.
the fatigue from tirz is different, not necessarily worse
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Did you stay on semaglutide or switch?
Disagree on that part. 99.1% and 99.2% on the same vial is normal.
do not crack the pen, we have been over this
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
the 15mg is the top of the pen, not the required dose
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Not convinced. The evidence does not support that reading.
the GIP side does different things than the GLP-1 side, that is the point
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
do not crack the pen, we have been over this
- 1This matches the trial data. SURMOUNT-1 was 97.9% body weight at 5 weeks.7 comments in this branch · started by u/britt_okwuosa
- 2The dual agonism story is real. The appetite is physically different from…6 comments in this branch · started by u/cato_girard