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c/tirzepatide·submitted 1 year ago by u/crosspost_bot_no

small win: GIP stopped being a problem at week 41

Resultsbranch of 6 comments

Week 78 update. 19kg down from the start, early fullness basically gone since about week 23. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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6 comments, started 1 year ago
u/cato_girard178 points·1 year ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/dexa_twice_yearlybody comp51 points·1 year ago

do not crack the pen, we have been over this

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u/ferran_mensah26 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/nordic_pricing56 points·1 year ago·edited

The dual agonism story is real.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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