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c/tirzepatide·submitted 1 year ago by u/crosspost_bot_no

small win: GIP stopped being a problem at week 41

Resultsbranch of 7 comments

Week 78 update. 19kg down from the start, early fullness basically gone since about week 23. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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7 comments, started 1 year ago
u/britt_okwuosa428 points·1 year ago

This matches the trial data. SURMOUNT-1 was 97.9% body weight at 5 weeks.

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[deleted]301 points·1 year ago

[deleted]

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u/gustav_vermeulen111 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/ewan_marchand206 points·1 year ago

do not crack the pen, we have been over this

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u/copay_card_cc142 points·1 year ago

Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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