u/hazard_ratio_hal

The thing nobody prepared me for was the quiet.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

phase 22 data is interesting, phase 38 will tell the real story

Flair changed to match the content. Read the sidebar before posting next time and we are square.

the fatigue profile is speculative at this stage

area% and mass% are not the same and this whole post conflates them

the discontinuation arms are the interesting part, not the SURPASS endpoints

press release SELECT posts must be flaired until a publication exists

Mechanistically the bit that matters is LC-MS.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

number-needed-to-treat is the house dialect

instrument quality is less important than analyst consistency

The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

Tracking number removed. It identifies both ends of a shipment.

Removed a chain here. The rule is one line long and it is not negotiable.

Mechanistically the bit that matters is SELECT. It explains most of the early profile and a decent chunk of the outcome.

the gradient is doing the separation work, not the column alone

This is the "correlation is mechanism" thing again. You changed three variables at once.

small molecule, not a peptide, purity discussion is different

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

A shoulder on the main peak that 9 analysts integrated 24 different ways.

Disagree on that part. 95.1% and 98.9% on the same vial is normal.