GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
414
c/trialwatch·posted 10 months ago by u/laila_almeida

[Meta] proposal — a flair for SURPASS posts

Press Release Sourced ×8

Posting this because I searched for it and got nothing useful.

Setup: 1.7mg, week 59, injection-site soreness present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 22 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

3,513 up / 3,099 down53% upvoted18 commentsid 4evl0e17 Sep 2025

18 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/rania_salinas34 points·10 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

replysharereportpermalink
u/hazard_ratio_halMOD19 points·10 months ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

replysharereportpermalink
load more comments (3) →
u/yara_bakken21 points·10 months ago

Yeah, absolute numbers matter more than the press release.

replysharereportpermalink
u/karl_fischer_kev15 points·10 months ago·edited

Disagree but this is the good kind of wrong — it is specific enough to be checked.

replysharereportpermalink
u/joaquin_trevino10 points·10 months ago

the 7 week readout is different from the 4 week readout

replysharereportpermalink
u/sofia_ferreira12 points·10 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

replysharereportpermalink
u/laila_almeidaOP7 points·10 months ago

dropout handling matters, especially on GI-heavy populations

replysharereportpermalink
u/niels_norgaard8 points·10 months ago

Yeah, absolute numbers matter more than the press release.

replysharereportpermalink
u/tove_ogunleye14 points·10 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

replysharereportpermalink
u/hsa_math4 points·10 months ago

This is correct. Discontinuation arms show the regain reality.

replysharereportpermalink
u/cesar_ivaturi5 points·10 months ago
wrong community but useful, so, shrug
replysharereportpermalink
u/anders_kuusela0 points·10 months ago

Mechanistically the bit that matters is SURMOUNT. It explains most of the early profile and a decent chunk of the outcome.

replysharereportpermalink
u/marit_laurent2 points·10 months ago·edited

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →