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c/trialwatch·posted 2 years ago by u/yusuf_ramos

[Question] Sweden — has anyone got a straight answer on SELECT

Readout Long Haul ×7 Slow Clap ×3 Clean Column ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking STEP against eGFR for 35 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

8,951 up / 3,218 down74% upvoted21 commentsid 15kzid23 Nov 2023

21 comments

6 in this archive, depth 3

best — the order this archive was captured in

u/blunt_coldbox_notes647 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/niels_norgaard-7 points·2 years ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/yusuf_ramosOP1 point·2 years ago

STEP 1 readout: 98.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/pancreatitis_scare1 point·2 years ago

event rates are more informative than hazard ratios alone

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u/naomi_ekstrom447 points·2 years ago·edited

Yeah, absolute numbers matter more than the press release.

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