[Meta] proposal — a flair for STEP posts
Week 73 update. 19kg down from the start, early fullness basically gone since about week 30.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Removed a chain here. The rule is one line long and it is not negotiable.
Which trial and what was the primary endpoint?
number-needed-to-treat is the house dialect
absolute risk reduction, not relative risk reduction, that is how you decide
This is correct. Discontinuation arms show the regain reality.
Mechanistically the bit that matters is SELECT. It explains most of the early profile and a decent chunk of the outcome.
Mechanistically the bit that matters is SELECT.
Yes, exactly this, and it is the bit that took me 52 weeks to accept.
Sceptical. If this were true we would see it reflected in the data and we do not.
absolute risk reduction, not relative risk reduction, that is how you decide
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
give the trial name, phase, n, and primary endpoint in the body
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
phase 2 is not phase 3, smaller n and shorter trial
Disagree but this is the good kind of wrong — it is specific enough to be checked.
the relative risk reduction in headlines is not the whole story
Strongly agree. Phase 2 is investigational, not conclusive.
event rates are more informative than hazard ratios alone
the 21 week readout is different from the 27 week readout
give the trial name, phase, n, and primary endpoint in the body
the relative risk reduction in headlines is not the whole story
- 1phase 2 is not phase 3, smaller n and shorter trial10 comments in this branch · started by u/hedda_adeyemi
- 2The practical rule people converge on is 28 days at fridge temperature after…5 comments in this branch · started by u/valeria_karlsen