u/ilias_kaufmann

This is correct. Rodent data is investigational, not predictive.

Is that mechanism or speculation?

Yeah, the incretin mechanism is doing the work here.

The appetite literature is interesting but rodent models do not scale linearly to human dosing.

This is correct. The co-agonism is real.

the 85 A1c trend is the answer

Week 73 for me and the honest summary is: 25kg down, reflux manageable, and I have thought about food maybe four times today.

rodent data must be labelled as rodent data

handlers in the community are rare and cautious

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

metformin combo is standard

Strongly agree. Cycle changes are documented.

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

Did anything else change in the same window?

I am going to push back on this slightly.

Poland here. Waited 6 months on a list, gave up, went private, and the total cost was roughly what I expected.

The confident tone is doing a lot of work that the evidence is not.

I am going to push back on this slightly.

Yeah, amylin is doing different work than GLP-1.

Adding to this: co-agonism is doing more work than the comment implies.

Second this question. I have wondered about CGM for 20 months and never seen a straight answer.