GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
1.2k
c/t2dglp1·posted 1 year ago by u/chidi_abubakar

A1c: the version I wish someone had shown me in week 1

Caution The Quiet One ×8 Sourced ×1

Week 75 update. 46kg down from the start, early fullness basically gone since about week 20.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

1,565 up / 329 down83% upvoted40 commentsid wdr36j21 Jan 2025

40 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/runa_grimaldi262 points·1 year ago

Strongly agree. A1c matters as much as weight.

replysharereportpermalink
u/ilias_kaufmann0 points·1 year ago

Second this question. I have wondered about CGM for 20 months and never seen a straight answer.

replysharereportpermalink
u/gustav_lindholm69 points·1 year ago

Yeah, glycaemic control is the original use.

replysharereportpermalink
u/fasting_insulin_fMOD149 points·1 year ago·edited

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

replysharereportpermalink
u/kian_verhoeven138 points·1 year ago

This is correct. Hypo risk is real.

replysharereportpermalink
u/sten_palacios37 points·1 year ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

replysharereportpermalink
[removed]17 points·1 year ago

[removed by moderator]

replysharereportpermalink
u/marisol_moreau20 points·1 year ago

the A1c change is the signal

replysharereportpermalink
u/nils_ferreira76 points·1 year ago

Came off after 33 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

replysharereportpermalink
u/ferran_batista69 points·1 year ago

Respectfully this is a sample of one presented as a finding.

replysharereportpermalink
u/a1c_arcT2D55 points·1 year ago·edited

Genuine question — what concentration were you at?

replysharereportpermalink
u/jonas_cardoso35 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

replysharereportpermalink
u/slow_logbook_notes3013 points·1 year ago

I love that this community will spend 40 comments on a detail.

Yes, exactly this, and it is the bit that took me 96 weeks to accept.

replysharereportpermalink
u/joaquin_stanescu11 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 23–5. Practical consequence: what you feel in week 1 is not what that dose does.

replysharereportpermalink
u/protein_first_pnutrition6 points·1 year ago

insulin and sulfonylurea interactions are real hypo risk

replysharereportpermalink
load more comments (2) →
u/piotr_bruun17 points·1 year ago·edited

Strongly agree. A1c matters as much as weight.

replysharereportpermalink
u/santiago_rasmussen-22 points·1 year ago

Strongly agree. A1c matters as much as weight.

replysharereportpermalink
u/slow_logbook_notes301 point·1 year ago

Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.

replysharereportpermalink
load more comments (8) →
u/osman_ferrari0 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.

replysharereportpermalink
u/neha_rahimi0 points·1 year ago

metformin combo is standard

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

36kmembers
62submissions
Jun 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/t2dglp1 rules
  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
  2. Post A1c with units and the assay date.
  3. No medication-stopping advice. Ever.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.