u/line_petrov

the fatigue from tirz is different, not necessarily worse

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

Did the reflux start before or after the dose increase?

Disagree. What you are describing is consistent with 15mg, not with what you concluded.

Which country? Half the answers in this thread only apply in Denmark.

Mechanistically the bit that matters is formulary. It explains most of the early profile and a decent chunk of the outcome.

constipation is real, boring, and fixable

Respectfully this is a sample of one presented as a finding.

handlers in the community are rare and cautious

Slight fix: the number was 97.4, not 97.2.

Adding to this: heart rate is doing more work than the comment implies.

the tendon rodent evidence is solid, human evidence is not

sulphur burps are disgusting but not dangerous, 19 weeks and they stopped

The confident tone is doing a lot of work that the evidence is not.

near-zero controlled human data, full stop

ask your actual doctor, not us

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Week 2 for me and the honest summary is: 39kg down, nausea manageable, and I have thought about food maybe four times today.

the muscle cramps passes. i promise. not medical advice.

Crossposting this to c/coldchain because the people who need it are not reading this community.

Adding to this: formulary is doing more work than the comment implies.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Respectfully this is a sample of one presented as a finding.