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c/sideeffects·posted 1 year ago by u/rohan_steiner

switched from 0.25mg to 1.7mg and the muscle cramps got better, not worse

PSA Clean Column ×9 Sourced ×2 Slow Clap ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking nausea against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

6,335 up / 659 down91% upvoted58 commentsid givkno29 Jul 2025

58 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/food_noise_gonemaintenance813 points·12 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/adaeze_brandt204 points·12 months ago

resting heart rate moved up 3 bpm and settled back down when I stopped escalating

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u/rohan_steinerOP117 points·12 months ago

How many weeks in are you? 22 weeks is noise, 5 weeks is a trend.

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u/enzo_danquah524 points·12 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/elin_lindqvist122 points·12 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/rohan_steinerOP70 points·12 months ago

Went to A&E convinced it was pancreatitis. Lipase normal. It was gallstones. Get checked, do not post and wait.

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u/rohan_steinerOP37 points·12 months ago

Yeah, the sulphur burps hit on day 22 for me too, not day 1.

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u/halima_mbeki352 points·12 months ago·edited

ask your actual doctor, not us

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u/quiet_moderatormod165 points·12 months ago·edited

IANAD and neither is anyone upvoting this

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u/vendorinvestigate_vic191 points·12 months ago

ask your actual doctor, not us

Adding to this: constipation is doing more work than the comment implies.

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u/salma_baptista-4 points·12 months ago

Slight fix: the number was 97.4, not 97.2. Decimal point, but a fairly consequential one.

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u/line_petrov1 point·12 months ago

Slight fix: the number was 97.4, not 97.2.

Adding to this: heart rate is doing more work than the comment implies.

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u/diego_sorensen300 points·12 months ago

You have restated the marketing copy. What is the actual substance here.

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u/sanne_laurent373 points·12 months ago

the nausea passes. i promise. not medical advice.

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u/slow_logbook_ftw284 points·12 months ago

the early fullness passes. i promise. not medical advice.

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[removed]269 points·12 months ago

[removed by moderator]

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u/ahmed_rasmussen161 points·12 months ago

hair loss is real and usually reversible when you stabilize

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u/sena_teixeira112 points·12 months ago

constipation is real, boring, and fixable

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u/priya_weiss86 points·12 months ago

week 3 and the the food-noise thing is finally getting better

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u/karma_irrelevant144 points·12 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/liv_vukovic252 points·12 months ago

I am going to push back on this slightly.

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u/ipamorelin_i202 points·1 year ago

the food-noise thing stops around week 71 for most people

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u/nausea_notesMOD143 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/quiet_moderatormod38 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/hassan_ostergaard38 points·12 months ago

Yeah, the reflux hit on day 14 for me too, not day 1.

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u/elin_trevino16 points·12 months ago

Yeah, the reflux hit on day 14 for me too, not day 1.

Yes, exactly this, and it is the bit that took me 36 weeks to accept.

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u/ayesha_erdogan138 points·1 year ago

the food-noise thing stops around week 71 for most people

Disagree on that part. 97.2% and 97.4% on the same vial is normal.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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