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crossposted from c/trialwatch by u/sanne_laurent — [Discussion] the endpoint advice in here is 5 years out of date
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c/tirzepatide·posted 10 months ago by u/bastian_ekstrom

nobody warned me about sulphur burps and I would have liked the warning

Trial Data Clean Column ×5 Cold Box ×1 Slow Clap ×1

Trying to settle this properly because the thread from last year went in circles.

The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything.

What would actually settle it is 35 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

4,749 up / 661 down88% upvoted37 commentsid ooxhuk26 Sep 2025

37 comments

14 in this archive, depth 4

best — the order this archive was captured in

u/titration_marshalMOD853 points·10 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/bastian_ekstromOP483 points·10 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/elin_varga357 points·10 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/hassan_nilsen-21 points·10 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/tidy_vialdrawer_pls628 points·10 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/bastian_ekstromOP379 points·10 months ago

Tried both. Sema worked, tirz worked better for me, but my sulphur burps profile was worse on tirz.

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u/sofia_nascimento263 points·10 months ago

week 40 on Mounjaro and the appetite profile is genuinely different from sema

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u/mikkel_kimani315 points·10 months ago

the 15mg is the top of the pen, not the required dose

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u/discount_math_dm422 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/tarek_kirchner143 points·10 months ago·edited

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/noor_hovland95 points·10 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/tarek_kirchner0 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/line_petrov415 points·10 months ago

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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