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c/tirzepatide·posted 10 months ago by u/search_before_post

genuine question about dual agonist that I am slightly embarrassed to ask

Question Cold Box ×3 Well Actually ×1

Quick one. Canada here.

15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 18 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

1,213 up / 296 down80% upvoted45 commentsid oyx3jj18 Sep 2025

45 comments

19 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivyMOD123 points·10 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[removed]59 points·10 months ago

[removed by moderator]

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u/slow_logbook_ftw49 points·10 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/nz_unfunded14 points·10 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/search_before_postOP43 points·10 months ago

the dual agonism hits different and that is why people describe it differently

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u/quiet_moderatormod13 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/tarek_kirchner43 points·10 months ago

This matches the trial data. SURMOUNT-1 was 99.2% body weight at 11 weeks.

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u/customs_seizure_sid113 points·10 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/aksel_kjaer166 points·10 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/crosspost_bot_no81 points·10 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/noor_hovland63 points·10 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/search_before_postOP90 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/line_petrov50 points·10 months ago

Disagree. What you are describing is consistent with 15mg, not with what you concluded.

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u/hub_opssite staff33 points·10 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/rania_marchand0 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/piotr_nascimento27 points·10 months ago

the dual agonism hits different and that is why people describe it differently

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u/crosspost_bot_no49 points·10 months ago

I am going to push back on this slightly.

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u/search_before_postOP19 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/aksel_kjaer54 points·10 months ago·edited

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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