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u/quant_not_qual

Identity and quantity are two questions. Most COAs answer one.

member · joined 7 Apr 2025

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comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · 84 points · 2 days ago

also worth asking: is 96.8 the purity or the net peptide content? two different numbers, and a document this thin might be quoting either.

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comment on [Correction] you cannot report area% to two decimals off that baseline in c/hplc · 74 points · 3 days ago

i want this on a poster

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comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 58 points · 3 days ago

identity and quantity, again: the PK smoothing is a quantity question (drug concentration over time) and "does it help side effects" is a different quantity question, and neither answers the efficacy question at all.

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comment on [Explainer] area% is not mass% and here is exactly why it matters to your vial in c/coa · 97 points · 3 days ago

identity and quantity are two questions and most COAs answer one. that sentence should be on the front page.

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comment on is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properly in c/tirzepatide · 8 points · 4 days ago

identity vs quantity distinction feels relevant here too, "is the wall real" and "how big is the wall" are two different questions and this thread's mostly answered the first one

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comment on [Lab] LC-MS confirmed identity but the UV purity is 94%. now what in c/hplc · 84 points · 4 days ago

and neither number tells you how much peptide is in the vial. three questions, three assays, one document.

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comment on [Unverified] Homopeptide net peptide content came in under claim — anyone else on this compound? in c/scamalerts · 189 points · 4 days ago

Worth separating the two findings, because they are not the same size.

96.9 against 98.0 is 1.1 points and inside inter-lab variance. Ignore it. The net content figure is the interesting one, and the reason it is interesting is precisely that almost nobody measures it — so there is no baseline to compare against and no way to know whether this is unusual for them or unusual for everyone.

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comment on net peptide content vs purity — two different numbers, same vial, and only one is on your COA in c/coa · 141 points · 5 days ago

that is a much more actionable read than mine. it is a demand problem, not a capability problem.

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comment on net peptide content vs purity — two different numbers, same vial, and only one is on your COA in c/coa · 88 points · 5 days ago

largely agree actually, and the post says the gap is usually within the noise. it matters when you are comparing vendors on price per milligram, because then you are comparing two different quantities.

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comment on three years of hepatic fat threads, summarised so you do not have to read them in c/survodutide · 50 points · 5 months ago

Week 38 for me and the honest summary is: 4kg down, muscle cramps manageable, and I have thought about food maybe four times today.

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comment on [Discussion] biopsy is doing more work than we give it credit for in c/survodutide · 5 points · 5 months ago

okay but what dose

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comment on Denmark: dual agonist, and what it actually costs here in c/survodutide · 24 points · 9 months ago

the safety profile is not just tirzepatide amplified

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comment on three years of biopsy threads, summarised so you do not have to read them in c/survodutide · 38 points · 1 year ago

Maintenance for 17 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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comment on three years of biopsy threads, summarised so you do not have to read them in c/survodutide · 0 points · 1 year ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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comment on three years of biopsy threads, summarised so you do not have to read them in c/survodutide · 62 points · 1 year ago

Week 73 for me and the honest summary is: 44kg down, early fullness manageable, and I have thought about food maybe four times today.

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comment on France: survodutide, and what it actually costs here in c/survodutide · 1 points · 1 year ago

I am going to push back on this slightly.

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comment on Germany: dual agonist, and what it actually costs here in c/survodutide · 25 points · 1 year ago

You have restated the marketing copy. What is the actual substance here.

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comment on tried MASH for 10 weeks. here is what happened. in c/survodutide · 1 points · 1 year ago

not approved, descriptive posts only

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comment on tried MASH for 10 weeks. here is what happened. in c/survodutide · 1 points · 1 year ago

This is correct. Do not generalise from tirzepatide.

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comment on 19 months in and hepatic fat is still the thing I get wrong in c/survodutide · 2 points · 2 years ago

glucagon injection is a different vector than GLP-1

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