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c/survodutide·posted 1 year ago by u/nora_ramos

tried MASH for 10 weeks. here is what happened.

Trial Data Receipts ×9 Long Haul ×1 Clean Column ×1

Genuinely asking, not being difficult.

Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I search I get 18 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

3,705 up / 251 down94% upvoted42 commentsid 1up9yk4 Oct 2024

42 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/milan_mensah420 points·1 year ago

Mechanistically the bit that matters is hepatic fat. It explains most of the early profile and a decent chunk of the outcome.

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u/clara_restrepo207 points·1 year ago·edited
okay but what dose
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u/sofia_ferreira-19 points·1 year ago

okay but what dose

Disagree on that part. 98.7% and 99.3% on the same vial is normal.

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u/quant_not_qual1 point·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/quant_not_qual1 point·1 year ago

not approved, descriptive posts only

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u/sofia_danquah190 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/employer_carveout99 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/nora_ramosOP37 points·1 year ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/zeynep_ndiaye9 points·1 year ago

not approved, descriptive posts only

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u/incretin_ivyMOD55 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/deleted_my_history28 points·1 year ago

Removed a chain here.

Adding to this: hepatic fat is doing more work than the comment implies.

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u/neha_rahimi29 points·1 year ago

the MASH indication changes the risk calculus

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u/tomas_lokken23 points·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/crosspost_bot_no20 points·1 year ago

not approved, descriptive posts only

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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Feb 2024created
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c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
  2. MASH claims need the trial and the biopsy endpoint.
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