c/survodutide · created 14 Feb 2024
GLP-1/glucagon dual agonist. MASH data and the hepatic angle.
The phase 2 MASH results ( NEJM , 2024) are, to me, the most underdiscussed thing in this whole space. Biopsy-confirmed endpoints. Not an ALT screenshot, not imaging,…
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks…
Posting this because I searched for it and got nothing useful. Setup: 15mg, week 49, sulphur burps present but not ruining anything. I changed exactly one variable —…
Vendor-level purity averages over time, built from independent results rather than vendor claims. Transparent methodology, open dataset.
Browse resultsWeek 21 update. 37kg down from the start, early fullness basically gone since about week 61. Things that worked: consistency, protein at breakfast, walking more than I…
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks…
Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 87, constipation present but not ruining anything. I changed exactly one variable —…
Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
dual agonist. That is the whole post, but I will justify it. Everything else people worry about in c/compounding is downstream of it. Titration speed, muscle cramps,…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker…
Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Genuinely asking, not being difficult. Everyone in c/tirzepatide repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I…
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last…
dual agonist. That is the whole post, but I will justify it. Everything else people worry about in c/meta is downstream of it. Titration speed, early fullness, the…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsQuick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Genuinely asking, not being difficult. Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I…
Right, the glucagon question again, but with numbers this time. I have 7 data points over 8 weeks. The pattern is consistent enough that I do not think it is chance,…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 31 weeks because I could not find anyone who had. The correlation is weaker…
Been lurking in c/dosinglogs for about 5 months and finally have something worth posting. Short version: week 21, 0.5mg, and glucagon is the bit I still cannot get a…
Been lurking in c/dosinglogs for about 15 months and finally have something worth posting. Short version: week 62, 1.7mg, and glucagon is the bit I still cannot get a…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker…
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last…
Genuinely asking, not being difficult. Everyone in c/tirzepatide repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I…
Been lurking in c/t2dglp1 for about 4 months and finally have something worth posting. Short version: week 44, 2.4mg, and hepatic fat is the bit I still cannot get a…
Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.
Independent testing plus vendor-level trend data. Community-funded, unaffiliated.
peptidemeter.comSeveral compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.
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