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c/survodutide·posted 3 months ago by u/meera_sandvik

tried MASH for 15 weeks. here is what happened.

Trial Data Clean Column ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking survodutide against ApoB for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

749 up / 138 down84% upvoted22 commentsid un4g0429 Apr 2026

22 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/nadia_kjaer64 points·3 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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[removed]46 points·3 months ago

[removed by moderator]

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u/tuva_kirchner67 points·3 months ago

rodent dual agonist is investigation only

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u/protein_first_pnutrition48 points·3 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/cesar_ivaturi22 points·3 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/clara_restrepo20 points·3 months ago

Strongly agree. The safety story is separate.

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u/rania_marchand-27 points·3 months ago

Phase 20 or 22?

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u/hana_lehtinen1 point·3 months ago

Phase 15 or 16?

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u/meera_sandvikOP1 point·3 months ago

This is correct. Do not generalise from tirzepatide.

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u/titration_marshalmod · c/semaglutide37 points·3 months ago·edited

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/elin_ferrari19 points·3 months ago·edited

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/liver_enzyme_lizMOD7 points·3 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/liver_enzyme_liz12 points·3 months ago
it is in the wiki actually
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u/cato_girard5 points·3 months ago

the MASH indication changes the risk calculus

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u/meera_sandvikOP4 points·3 months ago

rodent dual agonist is investigation only

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u/cato_batista3 points·3 months ago

the safety profile is not just tirzepatide amplified

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u/meera_sandvikOP1 point·3 months ago

Came off after 5 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/nora_ramos11 points·3 months ago

I am going to push back on this slightly.

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u/patient_labslip_log8 points·3 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/preservative_free_p6 points·3 months ago·edited

phase 10 data is interesting, phase 6 will be different

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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