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c/survodutide·posted 11 months ago by u/thermal_mass_tom

anyone else notice dual agonist kicking in around week 80

Trial Data Slow Clap ×1 Long Haul ×3

Week 39 update. 10kg down from the start, early fullness basically gone since about week 91.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

9,474 up / 6,901 down58% upvoted46 commentsid wl7yuv14 Aug 2025

46 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/marisol_frisk376 points·11 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/milos_mensa304 points·11 months ago

the GLP-1/glucagon dual is dual agonist, different from GIP/GLP-1

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u/certified_referenceQC-10 points·11 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/hugo_bergstrom1 point·11 months ago

phase 22 data is interesting, phase 14 will be different

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u/neha_rahimi1 point·11 months ago

Respectfully this is a sample of one presented as a finding.

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u/thermal_mass_tomOP1 point·11 months ago

Sweden here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/kaia_kuusela153 points·11 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/certified_referenceQC101 points·11 months ago

You have restated the marketing copy. What is the actual substance here.

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u/coa_janitormod · c/coa23 points·11 months ago

glucagon co-agonism has a different safety story

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u/elin_tamm7 points·11 months ago

glucagon injection is a different vector than GLP-1

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u/border_paperwork112 points·11 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/liv_vukovic93 points·11 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/preservative_free_p35 points·11 months ago·edited

do not generalise from tirzepatide

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u/crosspost_bot_no20 points·11 months ago

not approved, descriptive posts only

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[deleted]8 points·11 months ago

[deleted]

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u/nadia_kjaer8 points·11 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/trialwatch_theoMOD61 points·11 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/kian_ferreira49 points·11 months ago·edited

The nausea was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/sofia_danquah60 points·11 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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