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c/survodutide·posted 10 months ago by u/thermal_mass_tom

[Vendor] QST order #8 — Canada, 9 days, no drama, receipts inside

Discussion Clean Column ×7 Cold Box ×3

Confession thread, sort of.

I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 24 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 19 reads it before doing the same thing.

2,284 up / 369 down86% upvoted39 commentsid x5768t18 Sep 2025

39 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/incretin_ivyMOD412 points·10 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/rafael_sjoberg97 points·10 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/cato_girard-16 points·10 months ago

the heart rate signal is real in the data

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u/valeria_karlsen30 points·10 months ago

do not generalise from tirzepatide

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u/elin_tamm153 points·10 months ago

Small correction: the trial was 12 weeks, not 20. Does not change your point but people will quote it.

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u/injection_site_iris248 points·10 months ago

The confident tone is doing a lot of work that the evidence is not.

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[deleted]111 points·10 months ago

[deleted]

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u/refund_ledger26 points·10 months ago

rodent dual agonist is investigation only

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u/renzo_yildiz12 points·10 months ago

Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.

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u/elin_tamm164 points·10 months ago

not approved, descriptive posts only

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u/kaia_wojcik0 points·10 months ago

Which trial arm?

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u/hana_lehtinen1 point·10 months ago

the MASH indication changes the risk calculus

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u/dexa_twice_yearlybody comp1 point·10 months ago

Hepatic fat or MASH or what?

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u/draw_up_dizzy1 point·10 months ago

phase 15 data is interesting, phase 3 will be different

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
  2. MASH claims need the trial and the biopsy endpoint.
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