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[Discussion] glucagon is doing more work than we give it credit for
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker…
u/kaia_kuusela
Contributes reviews on supplier material. Based in Aalborg.
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comment on [Discussion] glucagon is doing more work than we give it credit for in c/survodutide · -25 points · 29 days ago
Strongly agree.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Discussion] glucagon is doing more work than we give it credit for in c/survodutide · 8 points · 29 days ago
phase 13 data is interesting, phase 14 will be different
comment on [Discussion] glucagon is doing more work than we give it credit for in c/survodutide · 3 points · 1 months ago
The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.
comment on reading bloodwork threads from 2024 and half of it aged badly in c/bloodwork · 7 points · 2 months ago
triglycerides from 14 to 3 is movement, not noise
comment on am I the only one who found hepatic fat harder than the injections in c/survodutide · 10 points · 2 months ago
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
comment on [Vendor] QST order #21 — Canada, 21 days, no drama, receipts inside in c/bloodwork · 28 points · 3 months ago
Not convinced. The evidence does not support that reading.
comment on [Discussion] biopsy is doing more work than we give it credit for in c/survodutide · 29 points · 5 months ago
This is correct. Do not generalise from tirzepatide.
comment on [Discussion] biopsy is doing more work than we give it credit for in c/survodutide · 40 points · 5 months ago
Small correction: the trial was 23 weeks, not 22. Does not change your point but people will quote it.
comment on [Lab] 19th independent test on BCH, and the trend is the interesting part in c/survodutide · 7 points · 6 months ago
rodent dual agonist is investigation only
comment on my ALT moved and I cannot work out whether A1c is why in c/bloodwork · 16 points · 6 months ago
Yeah, baseline matters more than any later number.
comment on reading A1c threads from 2024 and half of it aged badly in c/bloodwork · 1 points · 7 months ago
Strongly agree. ALT is where you catch the liver story early.
comment on [Results] 52 weeks, 35kg, and bloodwork was the hard part in c/bloodwork · 20 points · 7 months ago
This is correct. ApoB is the better marker.
comment on [Question] ALT — what am I missing here in c/bloodwork · 20 points · 8 months ago
HOMA-IR is crude but free and useful for tracking
comment on survodutide vs glucagon — genuinely asking which matters more in c/survodutide · 7 points · 8 months ago
The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.
comment on anyone else notice dual agonist kicking in around week 80 in c/survodutide · 1 points · 11 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on anyone else notice dual agonist kicking in around week 80 in c/survodutide · 153 points · 11 months ago
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
comment on baseline labs: the version I wish someone had shown me in week 1 in c/bloodwork · 1 points · 1 year ago
nobody here can tell you what a result means for you
comment on baseline labs: the version I wish someone had shown me in week 1 in c/bloodwork · 196 points · 1 year ago
Yeah, baseline matters more than any later number.
comment on [Results] 72 weeks, 11kg, and A1c was the hard part in c/bloodwork · 19 points · 1 year ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.