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c/survodutide·posted 2 months ago by u/lyophile_lou

am I the only one who found hepatic fat harder than the injections

Discussion

Right, the glucagon question again, but with numbers this time.

I have 7 data points over 8 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 43, not week 92. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

110 up / 33 down77% upvoted14 commentsid s580rd9 May 2026

14 comments

14 in this archive, depth 3

best — the order this archive was captured in

u/nora_ramos-32 points·2 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/kaia_kuusela10 points·2 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/yannick_petrov6 points·2 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/lyophile_louOP3 points·2 months ago

Stalled for 9 weeks, changed nothing, and it started moving again on week 87.

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[removed]4 points·2 months ago

[removed by moderator]

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u/incretin_ivyMOD7 points·2 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/peak_area_peteanalytical4 points·2 months ago

Australia here. Waited 3 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/honest_syringe_pls3 points·2 months ago

Phase 24 or 40?

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u/clara_restrepo8 points·2 months ago

Hepatic fat or MASH or what?

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u/vitamin_d_void2 points·2 months ago

the safety profile is not just tirzepatide amplified

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u/lyophile_louOP5 points·2 months ago

the UK here. Waited 19 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/patient_labslip_log5 points·2 months ago

This is correct. Do not generalise from tirzepatide.

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u/camila_trevino3 points·2 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/nadia_kjaer0 points·2 months ago

Strongly agree. The safety story is separate.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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