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c/bloodwork·posted 3 months ago by u/janek_ferrari

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Right, the ApoB question again, but with numbers this time.

I have 22 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 64, not week 18. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

9,348 up / 6,897 down58% upvoted54 commentsid 36ans112 Apr 2026

54 comments

28 in this archive, depth 5

best — the order this archive was captured in

u/elin_trevino356 points·3 months ago

baseline is the most important bloodwork measurement, you cannot collect it later

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u/liver_enzyme_lizMOD204 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/elin_trevino305 points·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/liv_okafor181 points·3 months ago

eGFR noise during rapid loss is expected

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u/mikkel_kimani125 points·3 months ago

Baseline ALT: 96.2. Week 61: 98.6. Same lab, fasted, same time of day. Trend matters.

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u/ravi_sandvik127 points·3 months ago

Do you have baseline to compare to?

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u/greta_chukwu33 points·3 months ago

HOMA-IR is crude but free and useful for tracking

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u/ravi_sandvik45 points·3 months ago

HOMA-IR is crude but free and useful for tracking

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/india_generic_g8 points·3 months ago

HOMA-IR is crude but free and useful for tracking

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u/ferran_halonen5 points·3 months ago

ferritin tanks quietly on a reduced appetite, check it

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u/janek_ferrariOP18 points·3 months ago

Baseline eGFR: 98.3. Week 77: 98.0. Same lab, fasted, same time of day. Trend matters.

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[removed]13 points·3 months ago

[removed by moderator]

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u/emil_okwuosa10 points·3 months ago·edited

Baseline eGFR: 98.3.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/janek_ferrariOP0 points·3 months ago

This is correct. ApoB is the better marker.

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u/lipid_panel_larrybloodwork4 points·3 months ago

ApoB from 20 to 39 is movement, not noise

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u/india_generic_g79 points·3 months ago

redact identifying details from lab PDFs before posting

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u/janek_ferrariOP30 points·3 months ago

baseline is the most important ferritin measurement, you cannot collect it later

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u/emeka_chowdhury70 points·3 months ago

eGFR noise on rapid loss is real. 18 week noise, 6 week trend. Do not panic at week 95.

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u/cormac_roos47 points·3 months ago

Strongly agree. ALT is where you catch the liver story early.

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u/leila_vasquez30 points·3 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/sanne_novak24 points·3 months ago

This is correct. ApoB is the better marker.

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u/thyroid_tangent45 points·3 months ago

HOMA-IR is crude but free and useful for tracking

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u/burned_once_twice34 points·3 months ago

post reference ranges with your numbers, units differ by country and lab

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u/yara_mensah42 points·3 months ago

Yeah, baseline matters more than any later number.

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u/india_generic_g0 points·3 months ago

eGFR noise on rapid loss is real. 6 week noise, 32 week trend. Do not panic at week 37.

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u/kaia_kuusela28 points·3 months ago

Not convinced. The evidence does not support that reading.

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u/emeka_chowdhury13 points·3 months ago

ALT is where the fatty-liver story shows up first

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u/nayeli_iyer8 points·3 months ago

You have restated the marketing copy. What is the actual substance here.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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