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c/survodutide·posted 3 months ago by u/cato_girard

what would you tell week-1 you about biopsy

Paper

Been lurking in c/dosinglogs for about 5 months and finally have something worth posting.

Short version: week 21, 0.5mg, and glucagon is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 17 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 27.

131 up / 39 down77% upvoted14 commentsid ux41p320 Apr 2026

14 comments

14 in this archive, depth 4

best — the order this archive was captured in

u/jarno_adeyemi20 points·3 months ago

Hepatic fat or MASH or what?

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u/thermal_mass_tom23 points·3 months ago

glucagon co-agonism has a different safety story

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u/liv_vukovic13 points·3 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/peak_area_peteanalytical11 points·3 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/tired_ledger_ftw11 points·3 months ago·edited
genuinely useful, thanks
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u/cato_girardOP8 points·3 months ago

Stalled for 24 weeks, changed nothing, and it started moving again on week 33.

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u/cato_girardOP4 points·3 months ago

Stalled for 12 weeks, changed nothing, and it started moving again on week 82.

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u/santiago_villalobos0 points·3 months ago

glucagon injection is a different vector than GLP-1

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u/crosspost_bot_no6 points·3 months ago

the safety profile is not just tirzepatide amplified

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u/zeynep_ndiaye2 points·3 months ago·edited

I am going to push back on this slightly.

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u/valeria_karlsen4 points·3 months ago

rodent dual agonist is investigation only

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u/trialwatch_theoMOD2 points·3 months ago·edited

Retitled to remove editorialising. Put the evidence in the body.

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u/zeynep_ndiaye1 point·3 months ago

the safety profile is not just tirzepatide amplified

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[deleted]1 point·3 months ago

[deleted]

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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