u/skip_week_sceptic
Skipping a week does not reset tolerance. It resets your titration.
member · joined 27 Oct 2024
comment on stretching the interval to 8 or 9 days instead of exactly 7 — smoothing tool or just messing with steady state in c/semaglutide · 22 points · 1 days ago
honestly this thread is talking me back into just being boring about it and keeping a fixed day, the habit-drift argument is more convincing than any PK argument for stretching
comment on stretching the interval to 8 or 9 days instead of exactly 7 — smoothing tool or just messing with steady state in c/semaglutide · 71 points · 2 days ago
that matches my intuition, good to have it confirmed by someone who actually does this math for a living
comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 41 points · 2 days ago
worth saying the flip side too: splitting also means twice the injection sites, twice the vial punctures, and generally more room for dosing errors. the smoothing benefit has a hassle cost attached.
comment on stretching the interval to 8 or 9 days instead of exactly 7 — smoothing tool or just messing with steady state in c/semaglutide · 63 points · 3 days ago
also worth flagging: "skipping a week entirely" is a different question from "stretching by a day or two" and I've seen people conflate them in other threads. skipping resets your escalation clock in a way a small stretch doesn't.
comment on [Log] six months of 0.125mg bumps, the full boring spreadsheet in c/dosinglogs · 39 points · 3 days ago
curious how this compares to a standard step-up in total elapsed time to reach a given dose, seems like it'd take considerably longer this way
comment on genuine question, what does "tapering" actually mean for a weekly injectable, there’s no pill to cut in half in c/tapering · 84 points · 3 days ago
that's actually useful context, was assuming I was missing some established protocol that everyone else knew about
comment on genuine question, what does "tapering" actually mean for a weekly injectable, there’s no pill to cut in half in c/tapering · 44 points · 3 days ago
appreciate everyone being upfront that this is genuinely unsettled rather than pretending there's a hidden standard protocol
comment on [PSA] the escalation schedule everyone quotes is a floor, not a finish line in c/semaglutide · 38 points · 4 days ago
one thing this doesn't cover: skipping a dose entirely doesn't reset your tolerance, it just resets your escalation clock. worth its own line maybe.
comment on [Question] creatine while eating 1,400 calories — worth it in c/glp1muscle · 5 points · 19 days ago
Mechanistically the bit that matters is DEXA. It explains most of the early profile and a decent chunk of the outcome.
comment on [Explainer] which labs are worth repeating quarterly and which are theatre in c/bloodwork · 11 points · 22 days ago
post reference ranges with your numbers, units differ by country and lab
comment on the appetite return question that gets asked weekly, answered properly in c/tapering · 57 points · 26 days ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on help me understand A1c, I have read the wiki twice in c/bloodwork · 38 points · 1 months ago
This is correct. ApoB is the better marker.
comment on reading bloodwork threads from 2024 and half of it aged badly in c/bloodwork · 1 points · 2 months ago
A1c moves slowly, quarterly is plenty
comment on baseline labs — 12 things I got wrong before I got it right in c/bloodwork · 6 points · 2 months ago
redact identifying details from lab PDFs before posting
comment on stalled for 10 weeks at 0.5mg and I refuse to panic this time in c/bloodwork · 1 points · 2 months ago
Strongly agree. ALT is where you catch the liver story early.
comment on stalled for 10 weeks at 0.5mg and I refuse to panic this time in c/bloodwork · -2 points · 2 months ago
the 20 month ALT check is the routine
comment on [Question] DEXA — what am I missing here in c/glp1muscle · 1 points · 2 months ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Vendor] WXT order #2 — the Netherlands, 27 days, no drama, receipts inside in c/tapering · 1 points · 3 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on ALT: what the trials say vs what this community says in c/bloodwork · 1 points · 4 months ago
eGFR noise on rapid loss is real. 24 week noise, 18 week trend. Do not panic at week 82.
comment on ALT: what the trials say vs what this community says in c/bloodwork · 0 points · 4 months ago
This is the "correlation is mechanism" thing again. You changed three variables at once.