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three years of SURMOUNT threads, summarised so you do not have to read them
Been lurking in c/glp1muscle for about 13 months and finally have something worth posting. Short version: week 95, 12.5mg, and SELECT is the bit I still cannot get a…
u/yannick_salinas
Contributes reviews on supplier material. Based in Ilorin.
member · joined 16 Jul 2025
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Overview — page 5 of 5
comment on three years of SURMOUNT threads, summarised so you do not have to read them in c/trialwatch · -33 points · 1 year ago
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
comment on three years of SURMOUNT threads, summarised so you do not have to read them in c/trialwatch · 286 points · 1 year ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on [PSA] TRIUMPH is not what most of this community thinks it is in c/retatrutide · 75 points · 1 year ago
That is net peptide content, not purity. Different number, different meaning.
comment on [Discussion] can we stop arguing about STEP until somebody posts a number in c/trialwatch · 4 points · 2 years ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Discussion] can we stop arguing about STEP until somebody posts a number in c/trialwatch · 12 points · 2 years ago
Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.
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[Discussion] can we stop arguing about STEP until somebody posts a number
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
comment on [Vendor] QST order #12 — Spain, 37 days, no drama, receipts inside in c/newbiequestions · 93 points · 2 years ago
The first time question took me three weeks to understand. Wiki explained it eventually.
comment on 20 months in and non-peptide is still the thing I get wrong in c/orforglipron · 32 points · 2 years ago
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
comment on [Discussion] the glucagon advice in here is 17 years out of date in c/retatrutide · 150 points · 2 years ago
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
comment on stalled for 17 weeks at 2.4mg and I refuse to panic this time in c/newbiequestions · 36 points · 2 years ago
What does the wiki say?
comment on stalled for 17 weeks at 2.4mg and I refuse to panic this time in c/newbiequestions · 1 points · 2 years ago
Pens or research vials?
comment on week 16 check-in — 46kg down, early fullness manageable, one thing confusing me in c/trialwatch · 1 points · 2 years ago
Which trial and what was the primary endpoint?
comment on tried retatrutide for 7 weeks. here is what happened. in c/retatrutide · 4 points · 2 years ago
TRIUMPH phase 2 showed 99.0% weight loss but the injection-site soreness profile on the highest arm was rough.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on what changed for me between week 10 and week 59 in c/retatrutide · 125 points · 2 years ago
Mechanistically the bit that matters is triple agonist. It explains most of the early profile and a decent chunk of the outcome.
comment on [Results] 2 weeks, 46kg, and phase 2 was the hard part in c/retatrutide · 751 points · 2 years ago
Which trial arm and what was the n?
Adding to this: phase 2 is doing more work than the comment implies.