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c/orforglipron·posted 2 years ago by u/deleted_my_history

20 months in and non-peptide is still the thing I get wrong

Discussion Slow Clap ×2 Receipts ×1

ACHIEVE. That is the whole post, but I will justify it.

Everything else people worry about in c/bpc157 is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort ACHIEVE out first, and almost nobody does.

I say this having got it wrong for 8 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

2,137 up / 377 down85% upvoted51 commentsid 1wwg1y18 Apr 2024

51 comments

26 in this archive, depth 4

best — the order this archive was captured in

u/pancreatitis_scare223 points·2 years ago·edited

the absorption problem is solved by non-peptide structure

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u/freya_marchand-11 points·2 years ago
yep. 17 weeks in, same.
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u/blank_injection103 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/yara_boateng37 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/rasmus_petrescu24 points·2 years ago

the absorption problem is solved by non-peptide structure

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u/erez_yilmaz78 points·2 years ago

the small molecule is whether this actually works long-term

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u/meera_sandvik19 points·2 years ago

the small molecule is whether this actually works long-term

Adding to this: non-peptide is doing more work than the comment implies.

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u/flair_enthusiast9 points·2 years ago

small molecule purity is different testing than peptides

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u/salma_almeida50 points·2 years ago

Genuine question — what concentration were you at?

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u/deleted_my_history41 points·2 years ago·edited

availability speculation must be flaired Speculation

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u/honest_syringe_maybe59 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/marit_coelho22 points·2 years ago

the early fullness profile is speculative at this stage

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u/chidi_yilmaz0 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/deleted_my_history16 points·2 years ago

the supply conversation changes if this approves

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[deleted]22 points·2 years ago

[deleted]

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u/bruno_dumitru44 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/yannick_salinas32 points·2 years ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/flair_enthusiast21 points·2 years ago

Did anything else change in the same window?

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u/lucia_bruun10 points·2 years ago

small molecule purity is different testing than peptides

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u/graph_it_gary4 points·2 years ago

small molecule purity is different testing than peptides

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/discount_math_dm6 points·2 years ago

the absorption problem is solved by non-peptide structure

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u/chidi_yilmaz3 points·2 years ago

Slight fix: the number was 96.8, not 99.2. Decimal point, but a fairly consequential one.

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u/hamza_weiss1 point·2 years ago

the supply conversation changes if this approves

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u/neha_mwangi1 point·2 years ago

the fatigue profile is speculative at this stage

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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