unpopular opinion: small molecule is massively overrated
Posting this because I searched for it and got nothing useful.
Setup: 10mg, week 47, constipation present but not ruining anything. I changed exactly one variable — non-peptide — and tracked it for 19 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
Strongly agree. The supply impact would be huge.
Has anyone actually got this in writing, or is it forum lore at this point?
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
ATTAIN and ACHIEVE are phase 3 trials
the ACHIEVE is whether this actually works long-term
small molecule purity is different testing than peptides
Disagree. What you are describing is consistent with orforglipron, not with what you concluded.
That is net peptide content, not purity. Different number, different meaning.
Half-life is about 168 hours, so steady state lands around week 8–5. Practical consequence: what you feel in week 1 is not what that dose does.
- 1Has anyone actually got this in writing, or is it forum lore at this point?8 comments in this branch · started by u/marit_sandvik