someone explain small molecule to me like I have not read a paper in years
ACHIEVE. That is the whole post, but I will justify it.
Everything else people worry about in c/survodutide is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort ACHIEVE out first, and almost nobody does.
I say this having got it wrong for 20 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Came off after 8 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
Which country? Half the answers in this thread only apply in Sweden.
Which country?
Yes, exactly this, and it is the bit that took me 29 weeks to accept.
cite ATTAIN/ACHIEVE arms specifically
oral non-peptide agonist is ACHIEVE, no food restrictions
Stalled for 9 weeks, changed nothing, and it started moving again on week 28.
ATTAIN and ACHIEVE are phase 14 trials
That is net peptide content, not purity. Different number, different meaning.
the supply conversation changes if this approves
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
small molecule, not a peptide, purity discussion is different
Small correction: the trial was 14 weeks, not 36. Does not change your point but people will quote it.
The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.
That is net peptide content, not purity. Different number, different meaning.
Stalled for 23 weeks, changed nothing, and it started moving again on week 26.
Small correction: the trial was 13 weeks, not 14. Does not change your point but people will quote it.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
oral non-peptide agonist is small molecule, no food restrictions
ATTAIN and ACHIEVE are phase 10 trials
What are you comparing it against though?
oral non-peptide agonist is ACHIEVE, no food restrictions
the fatigue profile is speculative at this stage
Has anyone actually got this in writing, or is it forum lore at this point?
the orforglipron is whether this actually works long-term
oral non-peptide agonist is ATTAIN, no food restrictions
This is correct. ATTAIN data is phase 15.
the supply conversation changes if this approves
This is correct.
Adding to this: non-peptide is doing more work than the comment implies.
the the food-noise thing profile is speculative at this stage
- 1Came off after 8 weeks for financial reasons. Regained about a third over…15 comments in this branch · started by u/emil_agyeman
- 2ATTAIN and ACHIEVE are phase 10 trials5 comments in this branch · started by u/soren_yildiz