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c/orforglipron·submitted 2 years ago by u/deleted_my_history

20 months in and non-peptide is still the thing I get wrong

Discussionbranch of 6 comments

ACHIEVE. That is the whole post, but I will justify it. Everything else people worry about in c/bpc157 is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort ACHIEVE out first, and almost nobody does. I say this having got it wrong for 8 months. My A1c was…

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6 comments, started 2 years ago
u/lucia_bruun10 points·2 years ago

small molecule purity is different testing than peptides

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u/graph_it_gary4 points·2 years ago

small molecule purity is different testing than peptides

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/discount_math_dm6 points·2 years ago

the absorption problem is solved by non-peptide structure

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u/chidi_yilmaz3 points·2 years ago

Slight fix: the number was 96.8, not 99.2. Decimal point, but a fairly consequential one.

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u/hamza_weiss1 point·2 years ago

the supply conversation changes if this approves

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u/neha_mwangi1 point·2 years ago

the fatigue profile is speculative at this stage

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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