three years of SURMOUNT threads, summarised so you do not have to read them
Been lurking in c/glp1muscle for about 13 months and finally have something worth posting.
Short version: week 95, 12.5mg, and SELECT is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 89.
best — the order this archive was captured in
Respectfully this is a sample of one presented as a finding.
This is correct. Discontinuation arms show the regain reality.
event rates are more informative than hazard ratios alone
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
This is correct. Discontinuation arms show the regain reality.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
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Is that absolute or relative risk reduction?
the relative risk reduction in headlines is not the whole story
Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.
Yeah, absolute numbers matter more than the press release.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
absolute risk reduction, not relative risk reduction, that is how you decide
number-needed-to-treat is the house dialect
I am going to push back on this slightly.
dropout handling matters, especially on GI-heavy populations
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Strongly agree. Phase 2 is investigational, not conclusive.
press release SURPASS posts must be flaired until a publication exists
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Yeah, absolute numbers matter more than the press release.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Tracking number removed. It identifies both ends of a shipment.
press release TRIUMPH posts must be flaired until a publication exists
STEP 1 readout: 97.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
- 1This is the "correlation is mechanism" thing again. You changed three…10 comments in this branch · started by u/yannick_salinas
- 2This is correct. Discontinuation arms show the regain reality.9 comments in this branch · started by u/aurel_mwangi