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Single comment threadYou are looking at one branch of three years of SURMOUNT threads, summarised so you do not have to read them — 51 comments in the full submission. View in context.
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c/trialwatch·submitted 1 year ago by u/yannick_salinas

three years of SURMOUNT threads, summarised so you do not have to read them

Trial Databranch of 9 comments

Been lurking in c/glp1muscle for about 13 months and finally have something worth posting. Short version: week 95, 12.5mg, and SELECT is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle. What I actually want to know is…

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9 comments, started 1 year ago
u/aurel_mwangi488 points·1 year ago

This is correct. Discontinuation arms show the regain reality.

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u/week_four_wall305 points·1 year ago·edited

event rates are more informative than hazard ratios alone

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u/yannick_salinasOP-33 points·1 year ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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u/ferran_dahlberg1 point·1 year ago

This is correct. Discontinuation arms show the regain reality.

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u/forest_plot_fionastats1 point·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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[removed]203 points·1 year ago

[removed by moderator]

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u/heart_rate_bump53 points·1 year ago

Is that absolute or relative risk reduction?

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u/yannick_salinas116 points·1 year ago

the relative risk reduction in headlines is not the whole story

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u/arne_ilunga100 points·1 year ago

Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.

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