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the co-agonism question that gets asked weekly, answered properly
Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…
Not convinced. The evidence does not support that reading.
tendon and co-agonism literature in rodents is interesting
This is the "correlation is mechanism" thing again. You changed three variables at once.
long-acting amylin is co-agonism, different satiety profile
The research community is small on cagrilintide. Forum lore changes faster than data.