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c/cagrilintide·submitted 1 year ago by u/amara_kuipers

CagriSema vs REDEFINE — genuinely asking which matters more

Questionbranch of 5 comments

Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

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5 comments, started 1 year ago
u/teodor_lokken277 points·1 year ago

the mechanism is different, the side effect profile reflects it

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u/yannick_salinas190 points·1 year ago

Disagree. What you are describing is consistent with CagriSema, not with what you concluded.

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u/liv_dumitru95 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/incretin_ivypharmacology73 points·1 year ago

tendon and CagriSema literature in rodents is interesting

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u/amara_kuipersOP43 points·1 year ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does CagriSema.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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