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c/cagrilintide·submitted 1 year ago by u/nl_verzekering

cagrilintide — my 24-week log, condensed into one table

Cautionbranch of 9 comments

co-agonism. That is the whole post, but I will justify it. Everything else people worry about in c/labresults is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort co-agonism out first, and almost nobody does. I say this having got it wrong for 5 months. My…

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9 comments, started 1 year ago
u/pancreatitis_scare17 points·1 year ago

This is correct. The co-agonism is real.

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u/nl_verzekeringOP7 points·1 year ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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[removed]5 points·1 year ago

[removed by moderator]

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u/nl_verzekeringOP4 points·1 year ago

[removed by moderator]

Adding to this: REDEFINE is doing more work than the comment implies.

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u/emil_agyeman2 points·1 year ago

Yeah, amylin is doing different work than GLP-1.

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u/milos_vestergaard4 points·1 year ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/nl_verzekering2 points·1 year ago

Disagree. What you are describing is consistent with REDEFINE, not with what you concluded.

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u/ledger_modmod · vetting1 point·1 year ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/zaid_grimaldi5 points·1 year ago

REDEFINE phase 12 readouts are interesting but 12 person satiety is different from 12 trial satiety.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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