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c/cagrilintide·submitted 6 months ago by u/lukas_vermeulen

[Meta] proposal — a flair for co-agonism posts

Labbranch of 8 comments

Been lurking in c/orforglipron for about 14 months and finally have something worth posting. Short version: week 88, 10mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 27 threads, and the answers split roughly down the middle. What I actually want to know…

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8 comments, started 6 months ago
u/milos_vestergaard98 points·6 months ago

Are we talking amylin or GLP-1 here?

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u/mateusz_adebayo56 points·6 months ago

Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/emil_agyeman27 points·6 months ago

Are we talking amylin or GLP-1 here?

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u/zeynep_ndiaye17 points·6 months ago

the amylin agonist pool is small, community is amylin

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u/hedda_aguirre24 points·6 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/liv_kuipers77 points·6 months ago·edited

Strongly agree. REDEFINE is phase 22, not final.

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u/hplc_hobbyistruns their own column27 points·6 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/lukas_vermeulen12 points·6 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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