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c/cagrilintide·submitted 11 months ago by u/freya_baptista

co-agonism — my 6-week log, condensed into one table

Discussionbranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 28, constipation present but not ruining anything. I changed exactly one variable — REDEFINE — and tracked it for 21 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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8 comments, started 11 months ago
u/nz_unfunded158 points·11 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/karim_restrepo46 points·11 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/freya_baptistaOP33 points·11 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/hana_pereira27 points·11 months ago

Yeah, amylin is doing different work than GLP-1.

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u/ahmed_fonseca8 points·11 months ago

amylin receptor distribution is different from GLP-1

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u/throwaway_44b138 points·11 months ago

Respectfully this is a sample of one presented as a finding.

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u/viktor_erdogan97 points·11 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/zeynep_ndiaye-22 points·11 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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