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c/cagrilintide·posted 1 year ago by u/milos_vestergaard

stalled for 18 weeks at 1.0mg and I refuse to panic this time

Question Cold Box ×7 Well Actually ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking cagrilintide against ApoB for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,132 up / 268 down89% upvoted34 commentsid 1bab0q30 Dec 2024

34 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/forest_plot_fionastats247 points·1 year ago

research use only, no human protocols in posts

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u/sanne_laurent71 points·1 year ago

I am going to push back on this slightly.

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u/lucia_bruun235 points·1 year ago

not approved anywhere, keep posts descriptive, not instructional

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u/milos_vestergaardOP95 points·1 year ago

Disagree. What you are describing is consistent with co-agonism, not with what you concluded.

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u/signe_grimaldi66 points·1 year ago

Disagree.

Yes, exactly this, and it is the bit that took me 54 weeks to accept.

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u/ravi_sandvik-24 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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