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c/cagrilintide·submitted 7 months ago by u/nz_unfunded

anyone else notice co-agonism kicking in around week 5

Labbranch of 7 comments

Been lurking in c/orforglipron for about 9 months and finally have something worth posting. Short version: week 6, 1.0mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 21 threads, and the answers split roughly down the middle. What I actually want to know is…

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7 comments, started 7 months ago
u/rina_sobczak133 points·7 months ago

This is correct. The co-agonism is real.

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[deleted]96 points·7 months ago

[deleted]

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u/zaid_balogun65 points·7 months ago

[deleted]

Disagree on that part. 97.4% and 98.3% on the same vial is normal.

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u/amara_halonen54 points·7 months ago

Yeah, amylin is doing different work than GLP-1.

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u/clara_weiss40 points·7 months ago

long-acting amylin is co-agonism, different satiety profile

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u/nadia_bakker19 points·7 months ago

This is correct. The co-agonism is real.

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u/rina_sobczak41 points·7 months ago

long-acting amylin is co-agonism, different satiety profile

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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