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c/cagrilintide·submitted 8 months ago by u/nadia_fonseca

small win: satiety stopped being a problem at week 30

Discussionbranch of 7 comments

Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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7 comments, started 8 months ago
u/incretin_ivyMOD69 points·8 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/noor_hovland35 points·8 months ago

long-acting amylin is co-agonism, different satiety profile

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u/liv_kuipers16 points·8 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/ferritin_low12 points·8 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/laila_dumitru48 points·8 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/bpc_scepticresearch peptides-38 points·8 months ago

the mechanism is different, the side effect profile reflects it

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u/ferran_halonen12 points·8 months ago

CagriSema is a fixed combo in trials, not user-mixed

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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