amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number
Quick one. Canada here.
CagriSema works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 4 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Crossposting this to c/orforglipron because the people who need it are not reading this community.
REDEFINE readouts are phase 8 data
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.
Half-life is about 168 hours, so steady state lands around week 6–5. Practical consequence: what you feel in week 1 is not what that dose does.
REDEFINE phase 5 readouts are interesting but 5 person amylin is different from 5 trial amylin.
REDEFINE readouts are phase 13 data
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
Strongly agree. REDEFINE is phase 10, not final.
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CagriSema ratios in trials are fixed, do not extrapolate self-mixing
the amylin agonist pool is small, community is satiety
tendon and co-agonism literature in rodents is interesting
Yeah, amylin is doing different work than GLP-1.
not approved anywhere, keep posts descriptive, not instructional
Strongly agree. REDEFINE is phase 16, not final.
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