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c/cagrilintide·submitted 1 months ago by u/noor_ivaturi

[PSA] satiety is not what most of this community thinks it is

Labbranch of 5 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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5 comments, started 1 months ago
u/iman_castellanos126 points·1 months ago

REDEFINE phase 23 readouts are interesting but 23 person REDEFINE is different from 23 trial REDEFINE.

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u/nadia_bakker33 points·1 months ago

This is correct. The co-agonism is real.

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u/protein_first_pnutrition27 points·1 months ago

Strongly agree. REDEFINE is phase 18, not final.

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u/amylin_amyamylin30 points·1 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/noor_ivaturi7 points·1 months ago

CagriSema is a fixed combo in trials, not user-mixed

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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